International Health
Volume 2, Issue 2 , Pages 103-113 , June 2010

Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole

  • José Carlos Sousa-Figueiredo

      Affiliations

    • WHO Collaborating Centre Schistosomiasis, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, United Kingdom
    • Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, United Kingdom
    • ,
  • Joyce Pleasant

      Affiliations

    • Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, United Kingdom
    • ,
  • Matthew Day

      Affiliations

    • Faculty of Medicine, University of Dundee, Nethergate, Dundee, DD1 4HH, United Kingdom
    • ,
  • Martha Betson

      Affiliations

    • WHO Collaborating Centre Schistosomiasis, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, United Kingdom
    • ,
  • David Rollinson

      Affiliations

    • WHO Collaborating Centre Schistosomiasis, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, United Kingdom
    • ,
  • Antonio Montresor

      Affiliations

    • Department of Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    • ,
  • Francis Kazibwe

      Affiliations

    • Vector Control Division, Ministry of Health, P.O. Box 1661, Kampala, Uganda
    • ,
  • Narcis B. Kabatereine

      Affiliations

    • Vector Control Division, Ministry of Health, P.O. Box 1661, Kampala, Uganda
    • ,
  • J. Russell Stothard

      Affiliations

    • WHO Collaborating Centre Schistosomiasis, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 (0)20 7942 5490.

Received 25 November 2009 ,Accepted 22 February 2010.

References 

  1. Gryseels B, Polman K, Clerinx J, Kestens L. Human schistosomiasis. Lancet. 2006;368:1106–1118
  2. Yamey G. The world's most neglected diseases. BMJ. 2002;325:176–177
  3. WHO. Deworming for health and development. Report of the third global meeting of the partners for parasite control (WHO/CDS/CPE/PVC/2005.14). Geneva: World Health Organization; 2005.
  4. WHO. The evidence is in: deworming helps meet the Millennium Development Goals (WHO/CDS/CPE/PVC/2005.12). Geneva: World Health Organization; 2005.
  5. WHO. World Health Assembly endorses WHO's strategic priorities. Geneva: World Health Organization; 2001.
  6. Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Ehrlich Sachs S, Sachs JD. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med. 2006;3:e102
  7. Fenwick A. New initiatives against Africa's worms. Trans R Soc Trop Med Hyg. 2006;100:200–207
  8. Fenwick A, Webster JP, Bosque-Oliva E, et al. The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008. Parasitology. 2009;1–12
  9. Kabatereine NB, Fleming FM, Nyandindi U, Mwanza JC, Blair L. The control of schistosomiasis and soil-transmitted helminths in East Africa. Trends Parasitol. 2006;22:332–339
  10. Bosompem KM, Bentum IA, Otchere J, et al. Infant schistosomiasis in Ghana: a survey in an irrigation community. Trop Med Int Health. 2004;9:917–922
  11. Guyatt HL, Brooker S, Donnelly CA. Can prevalence of infection in school-aged children be used as an index for assessing community prevalence?. Parasitology. 1999;118:257–268
  12. Odogwu SE, Ramamurthy NK, Kabatereine NB, et al. Schistosoma mansoni in infants (aged <3 years) along the Ugandan shoreline of Lake Victoria. Ann Trop Med Parasitol. 2006;100:315–326
  13. Sousa-Figueiredo JC, Basáñez MG, Mgeni AF, Khamis IS, Rollinson D, Stothard JR. A parasitological survey, in rural Zanzibar, of pre-school children and their mothers for urinary schistosomiasis, soil-transmitted helminthiases and malaria, with observations on the prevalence of anaemia. Ann Trop Med Parasitol. 2008;102:679–692
  14. Stothard JR, Gabrielli AF. Schistosomiasis in African infants and preschool children: to treat or not to treat?. Trends Parasitol. 2007;23:83–86
  15. Woolhouse MEJ, Mutapi F, Ndhlovu PD, Chandiwana SK, Hagan P. Exposure, infection and immune responses to Schistosoma haematobium in young children. Parasitology. 2000;120:37–44
  16. Montresor A, Stoltzfus RJ, Albonico M, et al. Is the exclusion of children under 24 months from anthelmintic treatment justifiable?. Trans R Soc Trop Med Hyg. 2002;96:197–199
  17. Stothard JR, Pleasant J, Oguttu D, et al. Strongyloides stercoralis: a field-based survey of mothers and their preschool children using ELISA, Baermann and Koga plate methods reveals low endemicity in western Uganda. J Helminthol. 2008;82:263–269
  18. WHO. Preventive Chemotherapy in Human Helminthiasis. Coordinated use of Anthelminthic Drugs in Human Interventions: a Manual for Health Professionals and Programme Managers. Geneva: World Health Organization; 2006.
  19. Montresor A, Odermatt P, Muth S. The WHO dose pole for the administration of praziquantel is also accurate in non-African populations. Trans R Soc Trop Med Hyg. 2005;99:78–81
  20. Saathoff E, Olsen A, Magnussen P, Kvalsvig JD, Becker W, Appleton CC. Patterns of Schistosoma haematobium infection, impact of praziquantel treatment and re-infection after treatment in a cohort of schoolchildren from rural KwaZulu-Natal/South Africa. BMC Infect Dis. 2004;4:40
  21. Johansen MV, Sacko M, Vennervald BJ, Kabatereine NB. Leave children untreated and sustain inequity!. Trends Parasitol. 2007;23:568–569
  22. Stothard JR, Gabrielli AF. Response to Johansen et al.: Leave children untreated and sustain inequity!. Trends Parasitol. 2007;23:569–570
  23. Brooker S, Kabatereine ND, Clements AC, Stothard JR. Schistosomiasis control. Lancet. 2004;363:658–659
  24. Katz N, Chavez A, Pellegrino J. A simple device for quantitative stool thicksmear technique in schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo. 1972;14:397–400
  25. Sorgho H, Bahgat M, Poda JN, Song W, Kirsten C, Doenhoff MJ, et al. Serodiagnosis of Schistosoma mansoni infections in an endemic area of Burkina Faso: performance of several immunological tests with different parasite antigens. Acta Trop. 2005;93:169–180
  26. Stothard JR, Kabatereine NB, Tukahebwa EM, Kazibwe F, Rollinson D, Mathieson W, et al. Use of circulating cathodic antigen (CCA) dipsticks for detection of intestinal and urinary schistosomiasis. Acta Trop. 2006;97:219–228
  27. Bennett A, Guyatt HL. Reducing intestinal nematode infection: efficacy of albendazole and mebendazole. Parasitol Today. 2000;16:71–74
  28. Hall A, Nokes C, Wen ST, Adjei S, Kihamia C, Mwanri L, et al. Alternatives to bodyweight for estimating the dose of praziquantel needed to treat schistosomiasis. Trans R Soc Trop Med Hyg. 1999;93:653–658
  29. Montresor A, Engels D, Chitsulo L, Bundy DA, Brooker S, Savioli L. Development and validation of a ‘tablet pole’ for the administration of praziquantel in sub-Saharan Africa. Trans R Soc Trop Med Hyg. 2001;95:542–544
  30. Ihaka R, Gentleman RR. A language for data analysis and graphics. J Comp Graph Stat. 1996;5:299–314
  31. Armitage P, Berry G. Statistical Methods in Medical Research.. 3rd ed.. Oxford: Blackwell Scientific Publications; 1994;
  32. Fisher RA. On the interpretation of Chi-square from contingency tables and the calculation of P. J R Stat Soc. 1922;85:87–94
  33. Kirkwood BR, Sterne JA. Essential Medical Statistics. 2nd ed.. Oxford: Blackwell Science; 2003;
  34. Williams CB. The use of logarithms in the interpretation of certain entomological problems. Ann Appl Bio. 1937;24:404–414
  35. Breslow NE, Clayton DG. Approximate Inference in Generalized Linear Mixed Models. J Am Stat Assoc. 1993;88:9–25
  36. Odongo-Aginya EI, Kironde FK, Kabatereine NB, Kategere P, Kazibwe F. Effect of seasonal rainfall and other environmental changes, on snail density and infection rates with Schistosoma mansoni fifteen years after the last snails’ study in Kigungu, Entebbe, Uganda. East Afr Med J. 2008;85:556–563
  37. Appleton CC, Ellery WN, Byskov J, Mogkweetsinyana SS. Epidemic transmission of intestinal schistosomiasis in the seasonal part of the Okavango Delta, Botswana. Ann Trop Med Parasitol. 2008;102:611–623
  38. Hotez PJ, Fenwick A, Savioli L, Molyneux DH. Rescuing the bottom billion through control of neglected tropical diseases. Lancet. 2009;373:1570–1575
  39. Helmby H. Schistosomiasis and malaria: another piece of the crossreactivity puzzle. Trends Parasitol. 2007;23:88–90
  40. Stoever K, Molyneux D, Hotez P, Fenwick A. HIV/AIDS, schistosomiasis, and girls. Lancet. 2009;373:2025–2026
  41. Stothard JR, Webster BL, Weber T, Nyakaana S, Webster JP, Kazibwe F, et al. Molecular epidemiology of Schistosoma mansoni in Uganda: DNA barcoding reveals substantial genetic diversity within Lake Albert and Lake Victoria populations. Parasitology. 2009;136:1813–1824
  42. Davis A. Antischistosomal drugs and clinical practice. In:  Jordan P,  Webbe G,  Sturrock RF editor. Human Schistosomiasis. Wallingford: CAB International; 1993;p. 367–404
  43. Kumar V, Gryseels B. Use of praziquantel against schistosomiasis - a review of current status. Int J Antimicrob Agents. 1994;4:313–320
  44. Utzinger J, N’Goran EK, N’Dri A, Lengeler C, Tanner M. Efficacy of praziquantel against Schistosoma mansoni with particular consideration for intensity of infection. Trop Med Int Health. 2000;5:771–778
  45. Raso G, N’Goran EK, Toty A, Luginbühl A, Adjoua CA, Tian-Bi NT, et al. Efficacy and side effects of praziquantel against Schistosoma mansoni in a community of western Cote d’Ivoire. Trans R Soc Trop Med Hyg. 2004;98:18–27
  46. Montero R, Ostrosky P. Genotoxic activity of praziquantel. Mutat Res. 1997;387:123–139
  47. Meyer T, Sekljic H, Fuchs S, Bothe H, Schollmeyer D, Miculka C. Taste, A new incentive to switch to (R)-praziquantel in schistosomiasis treatment. PLoS NTD. 2009;3:e357
  48. WHO. Soil-transmitted helminthiasis: Progress report on number of children treated with anthelminthic drugs: an update towards the 2010 global target. Wkly Epidemiol Rec 2008; 83: 237-252.
  49. Crawley MJ. Graphics. In: The R book. Chichester: Wiley; 2007, p. 135–82.

PII: S1876-3413(10)00019-7

doi: 10.1016/j.inhe.2010.02.003

International Health
Volume 2, Issue 2 , Pages 103-113 , June 2010

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