International Health
Volume 2, Issue 2 , Pages 79-81 , June 2010

Global application of therapeutic hypothermia to treat perinatal asphyxial encephalopathy

  • Sudhin Thayyil

      Affiliations

    • UCL Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, United Kingdom
    • Corresponding Author InformationCorresponding author.
    • ,
  • Zulfiqar A. Bhutta

      Affiliations

    • Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, P.O. Box 3500, Karachi 74800, Pakistan
    • ,
  • Siddarth Ramji

      Affiliations

    • Neonatal Division, Department of Pediatrics, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110 002, India
    • ,
  • Anthony M. Costello

      Affiliations

    • UCL Centre for International Health and Development, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    • ,
  • Nicola J. Robertson

      Affiliations

    • UCL Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, United Kingdom

Received 16 October 2009 ,Revised 22 November 2009 ,Accepted 17 March 2010.

References 

  1. Azzopardi D, Strohm B, Edwards AD, Dyet LE, Halliday HL, Juszczak E, et al. Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy. N Engl J Med. 2009;361:1574–1584
  2. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet. 2005;365:663–670
  3. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574–1584
  4. Edwards AD, Brocklehurst P, Gunn AJ, Halliday H, Juszczak E, Levene M, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ. 2010;340:c363
  5. Kapetanakis A, Azzopardi D, Wyatt J, Robertson NJ. Therapeutic hypothermia for neonatal encephalopathy: a UK survey of opinion, practice and neuro-investigation at the end of 2007. Acta Paediatr. 2009;98:631–635
  6. Lawn JE, Lee AC, Kinney M, Sibley L, Carlo WA, Paul VK, et al. Two million intrapartum-related stillbirths and neonatal deaths: Where, why, and what can be done?. Int J Gynaecol Obstet. 2009;107:S5–S19
  7. Bhutta ZA, Ali S, Cousens S, Ali TM, Haider BA, Rizvi A, et al. Alma-Ata: Rebirth and Revision 6 Interventions to address maternal, newborn, and child survival: what difference can integrated primary health care strategies make?. Lancet. 2008;372:972–989
  8. Bang AT, Paul VK, Reddy HM, Baitule SB. Why do neonates die in rural Gadchiroli, India? (Part I): primary causes of death assigned by neonatologist based on prospectively observed records. J Perinatol. 2005;25(Suppl 1):S29–34
  9. Sodemann M, Nielsen J, Veirum J, Jakobsen MS, Biai S, Aaby P. Hypothermia of newborns is associated with excess mortality in the first 2 months of life in Guinea-Bissau, West Africa. Trop Med Int Health. 2008;13:980–986
  10. Biggar WD, Bohn DJ, Kent G, Barker C, Hamilton G. Neutrophil migration in vitro and in vivo during hypothermia. Infect Immun. 1984;46:857–859
  11. Robertson NJ, Nakakeeto M, Hagmann C, Cowan FM, Acolet D, Iwata O, et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomized controlled trial. Lancet. 2008;372:801–803
  12. Burnard ED, Cross KW. Rectal temperature in the newborn after birth asphyxia. Br Med J. 1958;2:1197–1199
  13. Mathur NB, Krishnamurthy S, Mishra TK. Estimation of rewarming time in transported extramural hypothermic neonates. Indian J Pediatr. 2006;73:395–399
  14. Lawn JE, Kinney M, Lee AC, Chopra M, Donnay F, Paul VK, et al. Reducing intrapartum-related deaths and disability: Can the health system deliver?. Int J Gynaecol Obstet. 2009;170:S123–S142
  15. Thayyil S, Ayer M, Guhan B, Marlow N, Jacobs I, Costello AM et al. Whole Body Cooling Using Phase Changing Material In Neonatal Encephalopathy: A Pilot Randomised Control Trial. Proceedings of the Neonatal Society; 26 November 2009; London, UK. www.neonatalsociety.ac.uk/meetings/2009_autumn_abstracts.pdf [accessed 15 March 2010].

PII: S1876-3413(10)00022-7

doi: 10.1016/j.inhe.2010.03.003

International Health
Volume 2, Issue 2 , Pages 79-81 , June 2010

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