International Health
Volume 2, Issue 2 , Pages 99-102 , June 2010

Risk factors for mortality in AIDS-associated Kaposi sarcoma in a primary care antiretroviral treatment program in Malawi

  • Kathryn Chu

      Affiliations

    • Médecins Sans Frontières, 49 Jorissen St, Braamfontein 2017, Johannesburg, South Africa
    • Department of International Health, Johns Hopkins M, Baltimore, MD, USA
    • Corresponding Author InformationCorresponding author at: Unit 23B, No 14, Waverly Business Park, Wyecroft Road, Mowbray 7700, Cape Town, South Africa. Tel.: +27 79 895 2489; fax: +27 21 448 3128.
    • ,
  • Dalitso Misinde

      Affiliations

    • Médecins Sans Frontières, Thyolo, Malawi
    • ,
  • Moses Massaquoi

      Affiliations

    • Médecins Sans Frontières, Thyolo, Malawi
    • ,
  • Olesi Pasulani

      Affiliations

    • Médecins Sans Frontières, Thyolo, Malawi
    • ,
  • Beatrice Mwagomba

      Affiliations

    • Ministry of Health, Thyolo, Malawi
    • ,
  • Nathan Ford

      Affiliations

    • Médecins Sans Frontières, 49 Jorissen St, Braamfontein 2017, Johannesburg, South Africa
    • ,
  • Rony Zachariah

      Affiliations

    • Médecins Sans Frontières, Medical Department, (Operational Research Unit), Brussels, Belgium

Received 19 November 2009 ,Revised 25 February 2010 ,Accepted 7 April 2010.

References 

  1. Agaba PA, Sule HM, Ojoh RO, Hassan Z, Apena L, Mu’azu MA, et al. Presentation and survival of patients with AIDS-related Kaposi's sarcoma in Jos, Nigeria. Int J STD AIDS. 2009;20:410–413
  2. Makombe SD, Harries AD, Yu JK, Hochgesang M, Mhango E, Weigel R, et al. Outcomes of patients with Kaposi's sarcoma who start antiretroviral therapy under routine programme conditions in Malawi. Trop Doct. 2008;38:5–7
  3. Jones JL, Hanson DL, Dworkin MS, Jaffe HW. Incidence and trends in Kaposi's sarcoma in the era of effective antiretroviral therapy. J Acquir Immune Defic Syndr. 2000;24:270–274
  4. Tam HK, Zhang ZF, Jacobson LP, Margolick JB, Chmiel JS, Rinaldo C, et al. Effect of highly active antiretroviral therapy on survival among HIV-infected men with Kaposi sarcoma or non-Hodgkin lymphoma. Int J Cancer. 2002;98:916–922
  5. Murdaca G, Campelli A, Setti M, Indiveri F, Puppo F. Complete remission of AIDS/Kaposi's sarcoma after treatment with a combination of two nucleoside reverse transcriptase inhibitors and one non-nucleoside reverse transcriptase inhibitor. Aids. 2002;16:304–305
  6. Di Lorenzo G, Konstantinopoulos PA, Pantanowitz L, Di Trolio R, De Placido S, Dezube BJ. Management of AIDS-related Kaposi's sarcoma. Lancet Oncol. 2007;8:167–176
  7. Zachariah R, Fitzgerald M, Massaquoi M, Pasulani O, Arnould L, Makombe S, et al. Risk factors for high early mortality in patients on antiretroviral treatment in a rural district of Malawi. Aids. 2006;20:2355–2360
  8. Nasti G, Talamini R, Antinori A, Martellotta F, Jacchetti G, Chiodo F, et al. AIDS-related Kaposi's sarcoma: evaluation of potential new prognostic factors and assessment of the AIDS Clinical Trial Group Staging System in the Haart Era–the Italian Cooperative Group on AIDS and Tumors and the Italian Cohort of Patients Naive From Antiretrovirals. J Clin Oncol. 2003;21:2876–2882
  9. Schopper D, Upshur R, Matthys F, Singh JA, Bandewar SS, Ahmad A, et al. Research ethics review in humanitarian contexts: the experience of the independent ethics review board of Medecins Sans Frontieres. PLoS Med. 2009;6:e1000115
  10. Yu JK, Chen SC, Wang KY, Chang CS, Makombe SD, Schouten EJ, et al. True outcomes for patients on antiretroviral therapy who are “lost to follow-up” in Malawi. Bull World Health Organ. 2007;85:550–554
  11. Krown SE. Highly active antiretroviral therapy in AIDS-associated Kaposi's sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi's sarcoma. J Clin Oncol. 2004;22:399–402
  12. Zachariah R, Ford N, Philips M, Lynch S, Massaquoi M, Janssens V, et al. Task shifting in HIV/AIDS: opportunities, challenges and proposed actions for sub-Saharan Africa. Trans R Soc Trop Med Hyg. 2009;103:549–558
  13. Mills EJ, Ford N, Mugyenyi P. Expanding HIV care in Africa: making men matter. Lancet. 2009;374:275–276
  14. Meditz AL, Borok M, MaWhinney S, Gudza I, Ndemera B, Gwanzura L, et al. Gender differences in AIDS-associated Kaposi sarcoma in Harare, Zimbabwe. J Acquir Immune Defic Syndr. 2007;44:306–308

PII: S1876-3413(10)00025-2

doi: 10.1016/j.inhe.2010.04.001

International Health
Volume 2, Issue 2 , Pages 99-102 , June 2010

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